诺贝尔奖得主从网上赌博网站十大排行的实验室开始了他的研究生涯
图片来源:Dan Holmes
2023年10月2日
画斯曼 ’81, gsa马81, P’15, H’23, whose pioneering work in messenger RNA led to the lifesaving vaccinations that altered the course of the COVID-19 pandemic, 谁获得过诺贝尔生理学或医学奖, 与合作者一起 Katalin Kariko他是BioNTech RNA Pharmaceuticals的高级副总裁.
Weissman and Karikó both received an Honorary Doctorate of Science from 信誉好的赌博全部网址 at this year's 毕业典礼.
“正是在这里，我磨练了自己的批判性思维能力, 从夏皮罗学院的大一新生开始, and nurtured my passion for scientific exploration in Professor Gerry Fasman’s 生物化学 实验室,” 韦斯曼在讲话中说. “I learned the value of col实验室oration and open-mindedness while being an active student, 校园成员, 兼职活动家.”
信誉好的赌博全部网址 and the Rosenstiel Foundation awarded Weissman and Karikó the 第50届刘易斯年会. 罗森斯蒂尔基础医学研究奖 2021年2月. 两人都获得了这一殊荣 拉斯科 临床医学研究奖.
“Drew’s pioneering research in messenger RNA is a true breakthrough for science. 通过他富有远见的工作, 他不仅改变了大流行的进程, but has advanced human knowledge and understanding in ways that will shape vaccine research for generations to come. His remarkable achievement is one of the great scientific accomplishments of our time,网上赌博网站十大排行校长罗恩·利博维茨说.
A Lexington, Massachusetts native, Weissman followed his youthful passion for science to 信誉好的赌博全部网址. 他研究了 生物化学 和酶学, 满足医学预科要求, 开始了毕生的研究, 从教授开始 杰拉尔德Fasman的 实验室. 在教室和实验室外面, 他与其他学生一起致力于环境和种族正义, 以及投票权激进主义.
“来到布兰迪斯拓展了我的知识面. 我学到了政治, 我学到了心理学, 我学到了社会学, 我学到了音乐, 戏剧和歌剧. All of those things have continued to expand over my years after graduating. 所以，我认为这真的开阔了我的眼界。 讲话 当他收到 布兰迪斯校友成就奖 in 2021. “But my main focus was in the 实验室 doing research, and that's where I was happiest.”
Weissman graduated from 信誉好的赌博全部网址 with bachelor’s and master’s degrees and went on to earn his PhD and MD from the Boston University. 研究生毕业后, Weissman completed a residency at Beth Israel Deaconess Medical Center and a fellowship 在 National Institutes of Health (NIH), 在那里，他在. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases and chief medical adviser to President Joe Biden. 自1997年以来，他一直是医学教授 佩雷尔曼医学院 在 宾夕法尼亚大学.
“I'm still a basic scientist, I always will be,他说 during an April 2021 信誉好的赌博全部网址 event, 病毒战争:对抗COVID-19和其他病毒威胁的战斗. “Basic science is being able to take an idea, and test it and see if it works. 如果它不起作用，你就会做别的事情. 基础科学的职业生涯对我来说是非常令人满意的.”
通过艰苦的研究, 在挫折中坚持不懈, Weissman and Karikó found that by engineering a modified version of mRNA — which transports instructions to cells regarding the production of proteins — and then developing a system to deliver it, they could trick the immune system into thinking the body is infected with a virus and produce antibodies to create at least partial immunity. Their work laid the groundwork for the BioNTech/Pfizer and Moderna COVID-19 vaccines.
“Among the few positive consequences of the current pandemic are the successful efforts made worldwide to generate effective vaccines,” 迈克尔Rosbash, the Peter Gruber Endowed Chair in Neuroscience and 2017 winner of the Nobel Prize in Physiology or Medicine. “The most creative of these rely on the new messenger RNA technology pioneered by Kariko and Weissman. This is a great story where individual initiative in basic science has ended up having a remarkable real-world impact.”
在传统疫苗中, 比如水痘疫苗, 小儿麻痹症, 流感或狂犬病, 注射弱化或杀死的病毒, 欺骗免疫系统对抗疾病. 这种方法比合成mRNA更昂贵, 哪些可以被重新编程来对抗不同的疾病.
"The COVID-19 vaccine breakthrough is a great example of how basic science innovations, 比如韦斯曼和Karikó开创的RNA技术, 能对生物医学科学的发展产生巨大的影响吗,生化学家说。 卡罗尔Fierke网上赌博网站十大排行教务长兼学术事务执行副校长.
Weissman said his time as 生物化学 major at 信誉好的赌博全部网址 gave him “insights on how to develop hypotheses — how to think about them, 如何发展新的研究方向.” Rather than graduating in three years, he chose to stay a fourth and earn a master’s degree. He wrote his master's thesis on acetylation of DNA, part of the process of gene regulation.
“Drew’s pioneering research in messenger RNA is a true breakthrough for science. His remarkable achievement is one of the great scientific accomplishments of our time.”
网上赌博网站十大排行校长罗恩·利博维茨
信誉好的赌博全部网址, 他说, also taught him the value of a supportive community. 是医学预科, 他说, was “an incredibly stressful time … but I had the support of not only the students, 我的朋友们, 还有老师们.”
“他们希望我们成功，我认为这就是塑造我未来的原因. Where right now I have a lot of students in my 实验室 and I work with them to help them succeed, 这就是信誉好的赌博全部网址教我的,他说. “我认为真正让我印象深刻的是同僚合作, 协作性, 以及我在布兰迪斯建立的友谊. 这是一个非常温暖和支持的社区.”
